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These mediators include the inflammasome complex NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and tumor necrosis factor-alpha (TNF-), which in turn exacerbate the dendritic and synaptic impairments leading to neuronal death and promote AD progression [13,14,15]

Discussion Recent spectrometric analyses have revealed an extensive number of H1 PTMs that may be linked to chromatin structure and dynamics 11,43

Populations exposed to high concentrations of this toxic compound include smokers and second-hand tobacco smokers

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